What Is PuraPly® Antimicrobial?

PuraPly Antimicrobial is the first purified native collagen matrix with the antimicrobial polyhexamethylene biguanide (PHMB). PuraPly Antimicrobial can be used to manage bioburden while supporting healing across a wide variety of wound types, regardless of severity or duration.1

The Novel Technology of PuraPly Antimicrobial

Explore the novel technology combining purified native collagen with the broad-spectrum antimicrobial PHMB.


PuraPly Antimicrobial Provides Clinical Benefit in 3 Ways


1 Purified Type 1 native collagen matrix creates a durable biocompatible scaffold2


2 Effective barrier against a wide array of microorganisms2,3


3 PHMB is known to inhibit the formation of biofilm on the wound surface2

The Benefits of Collagen and PHMB

PuraPly Antimicrobial utilizes an inherently strong biocompatible fenestrated sheet of porcine-derived collagen coated with PHMB.3


  • Is a naturally occurring building block that supports healing4
  • Is the most abundant structural component of the dermal matrix4


  • Inhibits the formation of biofilm3
  • Does not impair wound healing, unlike other antimicrobials3
  • Has low cytotoxicity and high tissue compatability3

References: 1. PuraPly Antimicrobial [package insert]. Canton, MA: Organogenesis, Inc; 2015. 2. Data on file. Organogenesis, Inc. 3. Hübner NO, Kramer A. Skin Pharmacol Physiol. 2010;23(suppl):17-27. 4. Brett D. Wounds. 2008;20(12):347-356.